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Featured News Posted: December 16, 2025 People Press Release Hood Lab ISB’s Dr. Mary Brunkow Wins 2025 Nobel Prize in Physiology or Medicine ISB’s Dr. Mary Brunkow Wins 2025 Nobel Prize in Physiology or Medicine The prize recognizes foundational discoveries about regulatory T cells and the FOXP3 gene that redefined immune tolerance and opened avenues to treat autoimmune disease, enable transplantation, and advance immuno-oncology. ISB celebrates Dr. Brunkow’s leadership and collaborative science. ISB’s Dr. Mary Brunkow Wins 2025 Nobel Prize in Physiology or Medicine ISB’s Dr. Mary Brunkow Wins 2025 Nobel Prize in Physiology or Medicine Posted: October 23, 2025 Cancer People Press Release The Science Behind the Nobel Prize The Science Behind the Nobel Prize The pioneering work of Mary Brunkow and Fred Ramsdell began with a mysterious mutant mouse known as “scurfy,” leading them to identify the FOXP3 gene and unlock how regulatory T cells prevent autoimmune disease — discoveries that now point to new treatments in cancer and autoimmunity. The Science Behind the Nobel Prize The Science Behind the Nobel Prize More News Posted: May 14, 2026 Health Press Release Gibbons Lab Global Multiomics Study Reveals How Geography and Ethnicity Shape Human Biology Global Multiomics Study Reveals How Geography and Ethnicity Shape Human Biology An international team of researchers, including scientists from the Institute for Systems Biology, has conducted one of the most comprehensive molecular studies of human diversity to date. Published in Cell, the work reveals how ethnicity and geography influence metabolism, immunity, the microbiome, and biological aging — insights that could help advance precision medicine for diverse populations. Global Multiomics Study Reveals How Geography and Ethnicity Shape Human Biology Global Multiomics Study Reveals How Geography and Ethnicity Shape Human Biology Posted: May 12, 2026 Cancer Infectious Disease Press Release A New Window Into the Immune System: ISB Researchers Develop Powerful Platform to Decode CD4+ T Cells A New Window Into the Immune System: ISB Researchers Develop Powerful Platform to Decode CD4+ T Cells Researchers at the Institute for Systems Biology have developed a powerful new platform that can identify and deeply profile antigen-specific CD4+ T cells at unprecedented scale and resolution. Published in Nature Communications, the work could help accelerate vaccine design, improve immune monitoring, and advance next-generation cancer immunotherapies. A New Window Into the Immune System: ISB Researchers Develop Powerful Platform to Decode CD4+ T Cells A New Window Into the Immune System: ISB Researchers Develop Powerful Platform to Decode CD4+ T Cells Posted: May 7, 2026 Infectious Disease Press Release Baliga Lab How Host Stress May Prime Tuberculosis to Rapidly Gain Drug Resistance How Host Stress May Prime Tuberculosis to Rapidly Gain Drug Resistance ISB researchers show that oxidative stress generated by the host immune system can prime tuberculosis bacteria to rapidly evolve antibiotic resistance, revealing how resistance may begin before treatment. How Host Stress May Prime Tuberculosis to Rapidly Gain Drug Resistance How Host Stress May Prime Tuberculosis to Rapidly Gain Drug Resistance Posted: May 6, 2026 Press Release Moritz Lab Proteins and Disease Scientists Uncover 1,700+ Protein-like Molecules in the ‘Dark Proteome’ Scientists Uncover 1,700+ Protein-like Molecules in the ‘Dark Proteome’ ISB researchers help reveal a previously hidden layer of the human proteome, identifying a new class of protein-like molecules known as “peptideins” with potential implications for cancer, immunotherapy, and human disease. Scientists Uncover 1,700+ Protein-like Molecules in the ‘Dark Proteome’ Scientists Uncover 1,700+ Protein-like Molecules in the ‘Dark Proteome’ Posted: April 23, 2026 Events Health Kane Lab How the Body Ages: Exploring Frailty, Menopause, and the Biology of Healthspan How the Body Ages: Exploring Frailty, Menopause, and the Biology of Healthspan ISB’s Dr. Alice Kane explores the biology of aging, highlighting frailty as a key measure of healthspan, new biomarkers of aging, and insights into menopause and women’s health. How the Body Ages: Exploring Frailty, Menopause, and the Biology of Healthspan How the Body Ages: Exploring Frailty, Menopause, and the Biology of Healthspan Posted: April 15, 2026 Cancer Press Release Heath Lab The Drug That Stops Cancer Also Teaches It How to Escape The Drug That Stops Cancer Also Teaches It How to Escape ISB researchers reveal a darker side of targeted therapy: the same oncogene inhibition that shuts down cancer growth program can also ignite a stress-driven identity switch — revealing an early escape route that may shape the future of cancer treatment The Drug That Stops Cancer Also Teaches It How to Escape The Drug That Stops Cancer Also Teaches It How to Escape View All News

ISB News - Institute for Systems Biology (ISB)